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CA: A Cancer Journal for Clinicians, Vol 13, 130-134, Copyright © 1963 by American Cancer Society

Formulation and Evaluation of Chemotherapeutic Agents

¹ Assistant Director at the Southern Research Institute, Birmingham, Alabama.

Much more has come from the past quarter century of chemical, biologic, and clinical research in cancer chemotherapy than can be measured by the impact to date at the clinical level. With the biochemical and organic synthetic background and talent involved in the formulation of chemotherapeutic agents, the emergence of more diverse and reliable quantitative evaluation techniques for guidance of drug design, the improvement in interpretation of experimental data and the design of clinical trials, and the slow but certain improvement in understanding of clinical problems by experimentalists and experimental problems by clinicians— I am much more optimistic about the long-term future of chemotherapy and chemotherapy in combination with other therapeutic modalities than I was five years ago.

Finally, in spite of all the funds and effort that have been devoted to cancer research over the past quarter century, I predict that some research historian will write something like this a quarter of a century hence: "By 1962, cancer research was just passing out of its lag-phase; some of the basic knowledge which has since led to development of means for control of x per cent of the cancer problem was then at hand; chemists, biochemists, experimental biologists, and clinicians were beginning to develop mutual respect for and understanding of each other's problems, views, and contributions and were banding together for concerted effort on logical facets of the problem of cancer. During the past two decades the clinical impact of these interdisciplinary research efforts appears to be approaching a straight line when plotted on semi-log paper and shows no present indication of becoming asymptotic."

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