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This Article Full Text All Versions of this Article: CA.2007.0003v1 58/2/97    most recent Submit a letter to the editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Wang, X. Articles by Shin, D. M. Search for Related Content PubMed PubMed Citation Articles by Wang, X. Articles by Shin, D. M.

Application of Nanotechnology in Cancer Therapy and Imaging

Dr. Wang is Research Associate, Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA.
Dr. Yang is Associate Professor, Department of Surgery, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA.
Dr. Chen is Associate Professor, Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA.
Dr. Shin is Professor, Department of Hematology and Oncology and Otolaryngology; Director, Clinical and Translational Cancer Prevention Program; Co-Director, Translational Lung Aerodigestive Tract Malignancies Program; and Associate Director of Academic Development, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA.

    ABSTRACT

Recent developments in nanotechnology have provided researchers with new tools for cancer imaging and treatment. This technology has enabled the development of nanoscale devices that can be conjugated with several functional molecules simultaneously, including tumor-specific ligands, antibodies, anticancer drugs, and imaging probes. Since these nanodevices are 100 to 1,000-fold smaller than cancer cells, they can be easily transferred through leaky blood vessels and interact with targeted tumor-specific proteins both on the surface of and inside cancer cells. Therefore, their application as cancer cell-specific delivery vehicles will be a significant addition to the currently available armory for cancer therapeutics and imaging.